Single-cell imaging and mass spectrometry data reveal adenosine in the DNA of mammalian cells can be methylated by METTL3 to form N6-methyladenosine in response to DNA damage.

Scientists have revealed how a tiny chemical modification in RNA, known as m6A, plays a critical role in the progression of ...

N6-methyladenosine (m6A) is one such mechanism, where methyl groups are added to the N6 position of adenosine on RNA. Adding these methyl groups enhances RNA stability; however, their removal by ...

(A, B) Immunoblot analysis of liver tissues with m6A family and representative ... and potential fatality. N6-methyladenosine (m 6 A), a prevalent post-transcriptional mRNA modification ...

However, recent discoveries demonstrate that specific internal ribosome entry sites (IRES) and N6-methyladenosine (m6A) modifications enable circRNAs to undergo cap-independent translation.