Over the past decade, plasmid-based gene transfer has emerged as a promising strategy for gene therapy and vaccination. In fact, plasmid DNA vectors are opening the way for pre-clinical applications, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 13 (Jun. 21, 1994), pp. 5962-5966 (5 pages) In a search for trypanosome DNA sequences that permit ...

Targeted genetic modification using programmable nucleases such as zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) is of great value in biomedical research, ...

Kinetoplast DNA of Trypanosoma brucei is composed of a network of about 10,000 interlocked minicircle DNA molecules (1.0 kilobase) that are catenated with about 50 maxicircle DNA molecules (23 ...

A team from the Universidade da Beira, Portugal have developed a rapid and non-expensive analytical method for characterising minicircle DNA (mcDNA). This methodology represents the first analytical ...

New results have highlighted the advantages of minicircles over plasmids as they avoid unnecessary bacterial backbone sequences due to higher transfection efficiencies and offer benefits especially in ...

A collaboration of researchers from the Faculty of Physics of the University of Warsaw, Polish Academy of Sciences, Baylor College of Medicine, Rice University, University of Montana and University of ...

Healthy cells in our body release nano-sized bubbles that transfer genetic material such as DNA and RNA to other cells. It's your DNA that stores the important information necessary for RNA to produce ...