After inferring sequences of the protein's ancestors, the team tested proteins which might have had a higher RNA methyltransferase activity. Among these candidates, the team found a variant that ...

Unlike animals, plants do not possess an adaptive immune system with antibodies or T cells to fight viral infections. Instead, they rely on the RNA silencing system, which serves as their innate ...

Figure 3: The Dnmt1-interacting region of HDAC1 associates with methyltransferase activity. We transiently transfected 293T cells in culture dishes (15-cm diameter) with pCMV-Myc-Dnmt1 (20 μg ...

Single-cell imaging and mass spectrometry data reveal adenosine in the DNA of mammalian cells can be methylated by METTL3 to form N6-methyladenosine in response to DNA damage.