Neurons exhibit a remarkable level of cellular compartmentalisation that underpins their complex signalling capabilities and functional adaptability. A key component of this spatial organisation is ...

Researchers reveal that neurons can utilize a supremely localized internal store of calcium to initiate the secretion of neuropeptides, one class of signaling molecules through which neurons ...

Spinal gastrin-releasing peptide receptor-expressing (GRPR⁺) neurons play an essential role in itch signal processing. However, the circuit mechanisms underlying the modulation of spinal GRPR⁺ neurons ...

The exact origin of GABAergic (γ-aminobutyric-acid-releasing) interneurons, which are responsible for control the firing of the principal human cortical neurons, has remained unclear. In rodents all ...

The CSHL team traced local and long-range connections of chandelier cells in the mouse brain. Arrow heads point to two of the chandelier cell soma or cell bodies, from each of which hundreds of ...

The spread of tau pathology from the entorhinal cortex into the neighboring hippocampus region of the brain is thought to herald the onset of clinical symptoms in AD, but exactly what path does tau ...

Neurons are famously fragile, yet some injured cells manage to hang on, stabilize, and even reconnect. That quiet resilience ...