In the absence of their cognate ligand, dependence receptors trigger programmed cell death. This function is the defining feature of dependence receptors, which include members of several different ...

'Inside-out' signalling causes integrins such as lymphocyte function-associated antigen 1 (LFA1; also known as αLβ2 integrin) to switch from a bent form to an extended form that more easily binds ...

This is a preview. Log in through your library . Abstract The leukocyte integrins (CD11/CD18 or β 2-type integrins) are expressed exclusively on leukocytes and participate in many adhesion-dependent ...

This is a preview. Log in through your library . Abstract We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps ...

Researchers from the US and China summarize the role of integrins in cancer cells and the current status of anti-integrin therapy for cancer Globally, human hepatocellular carcinoma (HCC) is the sixth ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused immense suffering and economic hardship to millions of people worldwide. To date, the mechanism of infection by SARS-CoV-2 ...

A recent study from the University of Helsinki reveals that inhibiting certain adhesion receptors on the surface of dendritic cells, the main antigen-presenting cells of the immune system, enhances ...

A recent study from the University of Helsinki reveals that inhibiting certain adhesion receptors on the surface of dendritic cells, the main antigen-presenting cells of the immune system, enhances ...