It has recently become apparent that DNA methylation and histone modification pathways can be dependent on one another, and that this crosstalk can be mediated by biochemical interactions between ...

like proliferating out of control or resisting cell death pathways, two key features of cancer cells. The findings suggest that drugs targeting histone H3 lysine-4 methylation may be effective in ...

CHG methylation is typically found with the CHH variety. Every time a cell divides, it must replicate its genome and its epigenome. Plants have diverse pathways overseeing the faithful passage of the ...

Researchers have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. A professor of pediatrics-developmental biology and an assistant professor of ...

Key epigenetic mechanisms—such as DNA methylation, histone modifications ... the critical role of epigenetic mechanisms in HBV pathogenesis. By targeting these pathways, we can develop therapies that ...

while transcriptionally inactive chromatin was associated with K9 methylation. While this study supports the existence of gene regulation by a histone code, many more exciting questions remain.

EZH2, a core component of the Polycomb Repressive Complex 2 (PRC2), plays a fundamental role in silencing tumor suppressor genes through histone methylation. Its overexpression has been implicated ...