Because so many diseases, such as cancer ... The most popular of these treatments aim to alter either DNA methylation or histone acetylation. Inhibitors of DNA methylation can reactivate genes ...

Although considerable progress has been made towards understanding the dynamic landscape of histone-methylation regulation ... and their roles in disease. One area of significant interest is ...

particularly cancer and cardiovascular diseases. The article is published in the journal Frontiers of Medicine. These modifications, which include DNA methylation, histone modifications ...

Liver TET1 was found to promote metabolic dysfunction-associated steatotic liver disease (MASLD) by regulating CD36 ...

The findings suggest that drugs targeting histone H3 lysine-4 methylation may be effective in counteracting the effects of Polycomb mutations found in human diseases. More information: Cyril S.

New understanding of the molecular switch that regulates intestinal cell plasticity and regeneration could lead to better ...

The primary challenge in curing the disease lies in the persistence of covalently ... Key epigenetic mechanisms—such as DNA methylation, histone modifications, and the involvement of noncoding ...

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. Peter Dempsey, PhD, professor of ...

The critical role of EZH2, an essential epigenetic regulator, in cancer progression and treatment is underscored in this new review article published in Genes & Diseases. The study highlights the ...

To compact the DNA, plants use various epigenetic marks, including DNA methylation and modifications of the histone proteins that organize and package the DNA. These two marks reinforce each other ...