DNA methylation and histone modification influence each other during development. Histone methylation can help to direct DNA methylation patterns, and DNA methylation seems to serve as a template ...

Histone deacetylation and other modifications, particularly the methylation of lysine 9 within histone H3 (H3-K9) residues located in the histone tails, cause chromatin condensation and block ...

Scientists are intensely focused on epigenetic gene regulation because drugs can be developed to target specific histone modifications and switch specific genes "on" and "off." Methylation is one ...

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. Peter Dempsey, PhD, professor of ...

Investigating NAD+ metabolism and the interplay between S-adenosylhomocysteine and S-adenosylmethionine in histone methylation could provide insights into how metabolic reprogramming affects histone ...

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

These minichromosomes bind with histone and nonhistone proteins, becoming transcriptionally active and sustaining viral replication. Key epigenetic mechanisms—such as DNA methylation, histone ...

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding biological age. In a recent study published in the journal Science Advances ...

EZH2, a core component of the Polycomb Repressive Complex 2 (PRC2), plays a fundamental role in silencing tumor suppressor genes through histone methylation. Its overexpression has been implicated ...

To compact the DNA, plants use various epigenetic marks, including DNA methylation and modifications of the histone proteins that organize and package the DNA. These two marks reinforce each other ...