Iron overload, characterized by elevated serum ferritin levels, has long been associated with various systemic complications, yet its impact on skeletal health has not been as well understood. A ...

Patients with iron overload — serum ferritin > 1000 µg/L or a diagnosis of hemochromatosis or thalassemia — were 60% more likely to have an osteoporotic fracture during an up to 10-year follow-up than ...

Saturation of TfR1 leads to the dissociation of Hfe and the binding of the alter to the TfR2, which in turn influences the binding of BMP6 to its receptors on the membrane. Increased liver iron ...

Ferritin is a protein that’s produced in the body’s cells, and largely concentrated in the liver and immune system cells. Ferritin stores and releases iron, which is essential for producing red blood ...

Iron deficiency is the most common nutritional deficiency in the world, with up to 20% of menstruating women lacking in the mineral and up to 5% having iron deficiency anaemia, largely due to ...

—Researchers recently examined how different iron chelation medications—deferoxamine, deferiprone, and deferasirox—impacted iron stores and long-term health in patients with transfusion-dependent ...

Iron is an important mineral for the body that helps convert food into energy. Iron in the blood helps transport oxygen from the lungs to the rest of the body, which is essential for the proper ...