Researchers had observed enhancer RNAs before, but this was the first evidence of widespread enhancer transcription. In the years since, several other groups have reported finding eRNAs in various ...

The protein that performs transcription binds to the DNA at the promoter, which is typically found directly adjacent to the ...

Enhancer Biology lab studies gene regulation and genome architecture controlled by transcription factors using genome-wide functional genomics methods. Our aim is to understand enhancer malfunction ...

I am working on two projects aiming to answer the same broad question: what rules govern transcription of non-coding genomic elements, like enhancers. My ajointment positions me to tackle this ...

These sensitized enhancers displayed increased binding of PPARα, a transcription factor critical for ketogenesis. Notably, this adaptive response was absent in hepatocyte-specific PPARα ...