But the complement system is an oft-overlooked part of the immune system that could be exploited to create new therapies. It’s more than a decade since the first checkpoint inhibitor hit the ...

In recent years, the complement system has been implicated in the pathophysiology and progression of many disorders, notably modulating inflammation and causing endothelial and organ damage 1.

The complement system is a central component of innate immunity, consisting of a large family of plasma and membrane bound proteins that are critical for protection against bacterial infection and ...

They occur when a part of the immune system, called the complement system, doesn’t work as it should. Although these conditions are similar, they result from a breakdown of different parts of ...

The Complement group, headed by Prof. Seppo Meri, has for long had an interest in sorting out how and why the complement system contributes to disease pathogenesis, how the system is controlled and ...

The human complement system is a complex defense system that helps protect the body from pathogens. Similar to the coagulation system, the complement system consists of a cascade of proteases that ...

Iptacopan is an innovative, first-in-class oral small molecule that reversibly inhibits factor B—a crucial serine protease in the alternative pathway of the complement system. By targeting this ...

These are the classic glomerular disease signs. But they also, because of the hyperactivity, if you will, of the complement system, they're all often very inflamed. I know that's kind of a ...

Earlier this year, Apellis Pharma became the first company to claim FDA approval for a drug to treat the condition, Syfovre (pegcetacoplan), which also targets the complement system. Syfovre needs ...