With a few exceptions, eukaryotic chromosomes have a single centromere ... for assembly of the kinetochore, which is a protein complex essential to proper chromosomal segregation during mitosis.

We usually think of the chromosome segregation machinery as ensuring unbiased ... Our studies showed that selfish centromeres drive by amplifying the kinetochore pathway to recruit destabilizers, thus ...

and these kinetochore-microtubule attachments are necessary for proper chromosome segregation. Problems in kinetochore-microtubule attachment and chromosome segregation can lead to aneuploidy, which ...

During mitosis spindles attach a special structure of chromosome, which is called "centromere." In this study, we clarified how centromeres are formed on chromosomes. Disclaimer: AAAS and EurekAlert!

The centromere consists of centromeric DNA and a multiprotein complex, the kinetochore. The kinetochore ensures the correct distribution of chromosomes between the two daughter cells and ...

which enable chromosome congression and proper segregation during cell division. Defects in the structure or function of the centromere can lead to chromosome missegregation, which may in turn ...

This sets up an opportunity for “cheating,” or nonrandom segregation, for example during the first round of meiosis when bivalents are split into paired chromosomes, as chromosomes with centromeres ...

Aberrant chromosome segregation generates aneuploid cells and genome instability ... of Mps1 is a priming mechanism for Mps1 activation and critical for kinetochore targeting (Wang et al. 2008, Xu et ...