With a few exceptions, eukaryotic chromosomes have a single centromere that ensures their accurate segregation during mitosis. Chromosomes that lack centromeres segregate randomly during mitosis ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For ...

Scientists at EMBL have captured how human chromosomes fold into their signature rod shape during cell division, using a ...

In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a cellular machine composed of microtubules and their associated proteins. Spindles are built from ...

We usually think of the chromosome segregation machinery as ensuring unbiased, random segregation. As we learn in high school biology, if a diploid individual carries two different alleles of a gene ...

Unlike cancer cells, normal cells do not tolerate errors in chromosome segregation. This finding, which we published in Nature in 2018, suggested that the act of being unstable is itself critically ...

My research focuses on the segregation of chromosomes during cell division. Chromosomes are the bodies that contain our DNA and it’s critical that each cell has the correct DNA in the correct quantity ...

Based on these observations, he asserted that, though it was different in its segregation into sperm cells, the accessory chromosome was indeed a true chromosome (Sutton, 1902). The notion that ...

The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of the cell. Cells with an abnormal number of chromosomes consequently activate ...

Meiosis reduces ploidy by following one round of DNA replication with two rounds of chromosome segregation (Meiosis I and Meiosis II respectively). In Meiosis I homologous chromosomes separate, which ...

Chromosome Dynamics: Although genetic information is encoded in a one-dimensional array of DNA bases, all major DNA processes (replication, transcription and recombination) are controlled by changes ...