maintaining protein homeostasis (proteostasis) is essential for cell and organismal health. To accomplish this, cells have evolved a sophisticated network of protein quality control machines ...

Individual proteostasis regulators could, in principle, tackle multiple diseases involving protein ... normal homeostasis, and Morimoto speculates that a 15–20% boost in chaperones should ...

It is critical for cell survival that protein homeostasis (proteostasis) is maintained. Molecular chaperones are essential modulators of proteostasis networks, regulating aspects of protein quality ...

HSP90 is also a mediator of cellular homeostasis ... and stop the chaperone cycle, leading to client protein degradation. Because of the HSP90 client repertoire, HSP90 inhibitors may combat ...

To maintain homeostasis, intestinal epithelial cells (IECs) must efficiently manage protein production and ... to modulate the UPR. Chemical chaperones, such as 4-phenylbutyrate (4-PBA) and ...

Small-molecule inhibitors of copper chaperones: Targeting proteins like ATOX1 may help regulate copper homeostasis without disrupting essential biological functions. Nanomedicine-based therapies ...

This useful study provides incomplete evidence that TANGO2 homologs, including HRG-9 and HRG-10, are not heme chaperones but play a role in cellular bioenergetics and oxidative stress homeostasis.