The functional or native conformation of non-membrane-bound proteins is typically water soluble. Chaperones will help unstable proteins fold correctly, although some proteins misfold anyway.

Previous studies have shown that mammalian cells express several hundreds of molecular chaperones, proteins that preserve or change the three-dimensional conformation of existing proteins.

Previous studies have shown that mammalian cells express several hundreds of molecular chaperones, proteins that preserve or change the three-dimensional conformation of existing proteins.

as chaperones to rescue misfolded proteins is a novel concept. To set the record straight, we draw your attention to the paper where it was first reported in 1997 that specific substrates and ...

Proteins are the end products of the decoding process that starts with the information in cellular DNA. As workhorses of the cell, proteins compose structural and motor elements in the cell, and ...

A Rutgers biochemistry professor explains how omega-6 fatty acids found in Western diets can activate cellular growth pathways in certain breast cancers.

Aging is inevitable for most cell types in the human body, but hematopoietic stem cells (HSCs) seem to defy the process. They retain their self-renewing ability almost throughout an organism’s ...

To accomplish this, cells have evolved a sophisticated network of protein quality control machines consisting of molecular chaperones and energy-dependent proteases, which monitor the protein folding ...

interactions with chaperones and stress signalling sensor proteins. Other research topics include molecular characterization of complement proteins and their complexes with other proteins in ...

SppA is a homo-oligomeric membrane bound protein with either tetrameric or octomeric cyclic symmetry. It creates a bowl shaped structure with either four or eight active sites. Many of these enzymes ...