Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that ...

Small cell lung cancer is one of the most aggressive forms of cancer. It grows quickly and spreads early, which makes it very difficult to treat. Even though patients often respond well to ...

St. Jude Children's Research Hospital scientists have identified previously unknown functions of the enigmatic enzyme caspase-6. The findings show that caspase-6 is a key regulator of innate immunity, ...

Expression profiles associated with disease progression in non-small cell lung cancer. Background: Cisplatin is a platinum-based chemotherapeutic drug used for treating a variety of human cancers such ...

Rather than delivering a swift blow to neurons, a death protein found elevated in people with progressive supranuclear palsy (PSP) may exact its toll in a slower, more insidious way. According to a ...

Scientists use cell death, whether by apoptosis or necrosis, to evaluate the toxicity or effectiveness of substances of interest, including potential therapeutic agents. For example, researchers will ...

Caspase-2-mediated cleavage of tau at Asp314 generates a neurotoxic fragment, Δtau314, that drives early synaptic dysfunction in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). This ...

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard ...

A new study offers important mechanistic insights into a recently discovered CRISPR-guided caspase, or Craspase. Using cryo-electron microscopy (cryo-EM), researchers explained its target RNA cleavage ...

The primary interest of our lab is to investigate the molecular mechanisms of apoptosis and how they impact human health and disease. This focus has evolved to include the investigation of ...