Habegger is a professor in the UAB Department of Medicine Division of Endocrinology, Diabetes and Metabolism and also a scientist in the UAB Nutrition Obesity Research Center who studies how glucagon ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

Bile acids, synthesised from cholesterol in the liver, are central to lipid digestion but also serve as signalling molecules that regulate metabolism, inflammation and cellular homeostasis. In ...

Bile acid metabolism disorders encompass a range of rare, yet clinically significant, genetic conditions that disrupt the normal synthesis and regulation of bile acids by the liver. These conditions, ...

Primary bile acids are synthesized from cholesterol in the liver, which is transformed to cholic acid (CA) through the classical pathway and chenodeoxycholic acid (CDCA) as an alternative pathway.

Learn how this breakfast staple uses a unique gel-forming fiber to scrub your bloodstream and protect your heart from fatty ...

Statins, plant sterols and stanols are typically regarded as safe. Statins remain the most effective medication for reducing LDL cholesterol and lowering overall cardiovascular risk. Eating a balanced ...

Eggs, shrimp, and other once-forbidden foods now have the all-clear. Here are the surprising high-cholesterol foods experts say are the real culprits. The post The 9 Worst Foods for Your Cholesterol, ...

Bile acids are essential to digestion, by acting like a kind of detergent that breaks up fat molecules. Fat doesn't dissolve in water, but our digestive system is full of water, so the fat we consume ...

Sterols and bile acids, traditionally viewed as structural components and digestive surfactants, have emerged as critical ...

The image depicts gut microbes producing secondary bile acids to support the host’s immune defense against cancer. Microbiota-derived bile acids (shown in light green) blocked the androgen receptor ...