Centrosome duplication is under precise control and occurs only once in a normal mammalian cell cycle. Disruption of this process causes centrosome amplification, unequal segregation of chromosomes ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of ...

BRCA1-associated ring domain 1 (BARD1) is the main binding partner of BRCA1 and is essential for the tumour-suppressor functions of BRCA1. The BARD1–BRCA1 heterodimer has ubiquitin ligase activity ...

Mutations in BRCA1 do not appear to contribute significantly to the risk of prostate cancer progression, according to DNA test results from 450 prostate cancer specimens. The findings suggest that ...

The full name of the BRCA1 gene is “breast cancer 1, early onset,” and it codes for a tumor suppressor protein. Tumor suppressor proteins help repair DNA that has become damaged in order to ensure the ...

The BRCA1 gene is a sequence located on the long arm of chromosome 17, at position 17q21. The gene spans around 100 kilobases and codes for a tumor suppressor protein containing 1863 amino acids. This ...

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression. A new study led by The ...

Adjusting the TMIST study design to accommodate slower than expected accrual: ECOG-ACRIN EA1151. A phase 3 study to determine the breast cancer risk reducing effect of denosumab in women carrying a ...

They are genes commonly associated with breast cancer in women, but in fact men who carry certain mutations in their BRCA1 or BRCA2 genes are at higher risk of developing certain types of cancer ...

Breast cancer survivor Christina Applegate announced that she had her ovaries and fallopian tubes removed because she has the BRCA1 mutation — should you get tested? In 2008, Christina Applegate was ...