Ceramide buildup due to faulty transport triggers stress responses that lock cells into senescence, revealing a potential mechanism behind cellular aging and related diseases.

In a struggle that probably sounds familiar to dieters everywhere, the less a Caenorhabditis elegans (C. elegans) worm eats, the more slowly it loses fat. Now, scientists at Scripps Research have ...

A study conducted by researchers from the Pennington Biomedical Research Center (PBRC, United States), Proteimax Biotechnology (Israel), and the University of São Paulo's Biomedical Sciences Institute ...

When starved of oxygen during a heart attack or stroke, cells unleash a flurry of emergency measures to protect themselves and the body. For decades, scientists have observed that the body's ...

Scripps Research scientists discovered that specialized intestine cells (shown in green) in the C. elegans worm (gray) produce a peptide hormone that travels to the brain to control fat metabolism.

A small molecule could provide valuable help in combating the global epidemic of obesity. When it was fed to obese mice, the animals' metabolism sped up and their excess weight was shed. It is doing ...

BUFFALO, N.Y. — When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as replicative senescence, cells remain alive but no longer ...